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can i use niacinamide with salicylic acid

The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. Laura is currently working in healthcare education and writes for ScienceBecomesHer in her spare time. Some research suggests that glycolic acid, as well as other AHAs, also inhibit tyrosinase [45]. Alternatively, the new active might have been the tipping point, pushing your skin into a state of irritation. Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens, As caffeine is present in green tea, both ingredients naturally complement each other’s effects, Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer, In addition, the two antioxidants in combination have demonstrated the ability to improve the appearance of acne, Neostrata Restore Redness Neutralizing Serum, The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. I have both of these products from The Ordinary. But, that doesn’t mean these two can’t be part of your anti-acne routine, as well. In fact, a large randomized controlled study found that the combination of niacinamide and NAG worked really well at reducing pigmentation. Salicylic acid or benzoyl peroxide must be absorbed by the skin to be effective. Can You Use Vitamin C and Retinol Together? While UV radiation is the most damaging form of solar radiation for the skin, it only accounts for approximately 3-7% of total solar radiation. Bonus tips: Drink lots of water. Niacinamide (Vitamin B3) reduces visible congestion and blemishes, zinc balances the production of sebum (your skin’s oil). ‘Optimization of physiological lipid mixtures for barrier repair’. Then use The ordinary niacinamide 10% & zinc 1% for oil control you want. This can be in a toner or serum form. When using hyaluronic acid and retinol, apply retinol first, then hyaluronic acid. For example, in a study that incubated human skin for 48 hours with centella asiatica, vitamin A, vitamin E, vitamin C, and their combinations, each ingredient, alone, increased the production of collagen two-fold (2x). Park, S., Seok, J., Kwak, J. et al. ‘Treatments Improving Skin Barrier Function’. Also to know i can mix Gycolic Acid with Vitamin C. Yeah! ‘The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer’. ‘Near visible light and UV photoprotection in the treatment of melasma: a double-blind randomized trial’. The addition of iron oxide to sunscreens also happens to broaden the UV protection of mineral sunscreen agents into the longer UVA and visible light spectrums. Lowe, N. (2006). Castanedo-Cazares, J., Hernandez-Blanco, D., Carlos-Ortega, B., Fuentes-Ahumada, C. & Torres-Alvarez, B. Salicylic acid could dry your skin and cause flakiness, tightness, and itchiness if you don’t moisturize your skin enough. Follow all instructions closely. 82, 1123– 1131. Ezra, if you have oily, acne-prone skin stop using a AHA exfoliator and switch to salicylic acid. Jagdeo, J. As the stratum corneum is the first to absorb the oxidative stress from free radicals produced by UV radiation, the levels of vitamin E in the skin are often depleted and regular topical application of vitamin E is recommended [18]. Vitamin C + Vitamin E + Ferulic Acid = Increased Effect Of Vitamin C By 8x. Zinc Oxide + Iron Oxide = Increased Photoprotection, Reduced Hyperpigmentation. ‘Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes’. (2005). In fact, the anti-aging effects of vitamin C are enhanced even further when it is combined with, Timeless Skincare 20% Vitamin C, E, & Ferulic Acid Serum, SeoulCeuticals Day Glow Serum 20% Vitamin C, E, & Ferulic Acid Serum With Hyaluronic Acid. Kimball, A., Kaczvinsky, J., Li, J., Robinson, L. et al. ‘Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin’. All content, including, but not limited to, text, images, links, and other material does not constitute medical or other professional advice, and is not intended to be a substitute for professional medical advice. Like UV radiation, visible light can also lead to the production of free radicals. (2013). Read More. <3 Yet another example of more is more in skincare! Telang, P. (2013). This basically means that niacinamide prevents pigment leaking into other surrounding cells. Davis, E. & Callender, V. (2010). ‘Anti-melanogenic effects of resveratryl triglycolate, a novel hybrid compound derived by esterification of resveratrol with glycolic acid’. According to Maiman, the combination of azelaic acid, niacinamide and salicylic acid are “generally considered safe for both pregnant and lactating … Niacinamide offers similar benefits [4], as well as reducing redness and pigmentation and improving skin barrier function [2]. These effects are largely down to the polyphenols (antioxidant molecules) that are naturally present in green tea. Related Reading: Niacinamide & Retinol Together = A Perfect Pair! Sound simple enough, right? Products That Combine N-Acetyl Glucosamine & Niacinamide: We have discussed 12 examples of skincare ingredient combinations where less is not more. It’s how they keep the price so low, but it also counteracts with makeup and sometimes with other products. Vitamin C and vitamin E are possibly the best example of a skincare power couple as they each enhance the effects of the other. Manela-Azulay, M. & Bagatin, E. (2009). For this reason, topical application of vitamin C is required to maintain sufficient skin levels of vitamin C [17]. ‘New insights in photoaging, UVA induced damage and skin types’. As salicylic acid is oil-soluble, it easily penetrates pores in order to unclog them by loosening and detaching the skin cells and debris that build up within the hair follicle [5]. ‘Pharmacological review on centella asiatica: A potential herbal cure-all’. Similar levels of free radical protection are also offered when antioxidants are used alone, Replenix Antioxidant Sunscreen Moisturizer, Murad City Skin Age Defense Broad Spectrum SPF 50 PA++++, La Roche-Posay Anthelios Melt-In Sunscreen Milk SPF 60, Heliocare 360º Gel Oil-Free SPF 50 Sunscreen, However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. Hashim, P. (2014). Infrared radiation accounts for about 53% and, Unfortunately, sunscreen is only able to block about 55% of the free radicals produced by UV exposure, and, alone, provides no protection from the free radicals produced by either infrared radiation or visible light, When added to sunscreen, antioxidants are able to reduce the production of free radicals by up to 78%. Niacinamide 10% + Zinc 1% Salicylic Acid 2% Solution Anhydrous Solutions = 2 Add number 2 to all these products if you have them. Hello! While all patients experienced reductions in hyperpigmentation, those who used the iron oxide sunscreen experiences significantly greater improvements [42]. (2014). Vitamin C and glycolic acid are also useful for treating hyperpigmentation as both are effective at inhibiting tyrosinase and decreasing melanin production [53][45]. They basically ‘mop-up’ the damage done by UV radiation and other environmental aging factors (smoking, pollution, etc.) Let us know in the comments section! Furthermore, niacinamide appears to have an additive effect when combined with NAG. Niacinamide & Retinol Together = A Perfect Pair! that is known to reduce pigmentation and inflammation and has anti-aging properties [43]. It is recommended to use a mild amino acid facial cleanser to clean the face. Kim, W. (2013). (2010). Song, X., Xu, A., Pan, W. et al. The Ordinary Salicylic Acid 2% Solution is a direct acid. Other ingredient combinations to check out: Have you found any skincare ingredient combinations that work particularly well? Derma E Acne Blemish Control Treatment Serum: A gentle 0.5 percent salicylic acid serum, with niacinamide around the middle of the ingredients list. Gohli, K., Patel, J. Still, if both ur niacinamide and Vit C (LAA) are in 2 different products, then just separate the order and use one in AM/PM lah. While all patients experienced reductions in hyperpigmentation, those who used the iron oxide sunscreen experiences significantly greater improvements, Murad City Skin Age Defense Broad-Spectrum SPF 50 PA++++, Skinceuticals UV Defense Broad-Spectrum SPF50 Physical Fusion Sunscreen, Tizo 3 Tinted Face Mineral SPF40 Sunscreen, Another great skincare ingredient combination for, Resveratrol is the potent antioxidant found in grapes (and red wine!) Thank you. Vitamin E returns the favor by increasing the action of vitamin C four-fold (4x) [19][20]. (1991). Liebel, F., Kaur, S., Ruvolo, E., Kollias, N. & Southall, M. (2012). ‘RALGA (Diacneal), a retinaldehyde and glycolic acid association and post-inflammatory hyperpigmentation in acne – a review’. This basically means that niacinamide prevents pigment leaking into other surrounding cells. I’m not sure why you’re using alpha arbutin as that’s a spot treatment for dark spots. The Ordinary! Because they both tackle the same issues and I feel like they work best when teamed up, I decided to combine the two products into one review. http://theordinary.com/product/rdn-niacinamide-10pct-zinc-1pct-30ml?redir=1, http://theordinary.com/product/rdn-salicylic-acid-2pct-solution-30ml?redir=1. Recommended Reading: Can You Use Glycolic Acid and Retinol Together? ‘Comparitive study of the effect of 50% pyruvic and 30% salicylic peels on the skin lipid film in patients with acne vulgaris’. & Lim, H. (2008). Usuki, A., Ohashi, A., Sato, H., Ochiai, Y., Ichihashi, M. & Funasaka, Y. However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. However, NAG can be unstable when used alone [62]. (2008). Another great antioxidant pairing is green tea and caffeine. These come up especially around my time of the month and whenever I use a wrong product (hello, over-sensitive skin!). Therefore, it was recommended that in order to achieve optimal results from both ingredients, the two should be used separately. Loden, M. (2016). Combining niacinimadie’s oil-reducing prowess with salicylic acid’s ability to dissolve excess oil is a great way to help keep pores clear and breakouts at bay. For example, 2% NAG, alone, reduced the appearance of facial hyperpigmentation, but this reduction was far greater when 2% NAG was combined with 4% niacinamide. Considering the price, it is probably best to save this product just for the dark spots that rea In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application [31]. As you can imagine, the two combined may be quite irritating for skin. I use the Niacinamide + Zinc first, all over my face (except for my nose, eyes and mouth area!) Since alpha and beta hydroxy acids are usually acidic, the application creates the perfect environment on your skin for vitamin C. Dreno, B., Nocera, T., Verriere, F. et al. Laura is a skincare addict and sunscreen enthusiast with more than 10 years of experience working in healthcare and over 5 years of experience working as a nurse. This is particularly the case when it comes to reducing pore size. This also means that salicylic acid can access sebaceous glands and reduce sebum production [6]. Lee, T., Seo, J., Baek, S. & Kim, S. (2014). The addition of, Like UV radiation, visible light can also lead to the production of free radicals. Although, resveratrol, alone, performed similarly well to the combination [47]. Before all that, you have to know where to start. This suggests that the combination of zinc oxide and iron oxide in sunscreen is particularly beneficial for individuals with melasma. Specifically, 4% niacinamide combined with 2% NAG was significantly more effective at reducing pigmentation than a vehicle control formulation [64]. Your email address will not be published. ‘Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity’. Thank you again. Post Inflammatory Erythema: 12 Effective Treatment Options. ‘Practical uses of botanicals in skin care’. Haftek, M. Mac-Mary, S., Le Bitoux, M. et al. ‘The extracellular matrix of stratum corneum: role of lipids in normal and pathological function’. For this reason, the combination of vitamin C and centella asiatica may lead to improved anti-oxidant, collagen-boosting, and wound-healing effects. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration [28]. But how do we know which skincare ingredients work well together? TruSkin Vitamin C … Do not take salicylic acid (psoriasis or seborrheic dermatitis) by mouth. It started about a year ago. I like how my skin looks after using for a few days! The greasy T-zone had always been there, but the under-skin bumps on my forehead and red, spotty patches were new. Both have anti-aging and anti-acne effects and offer some level of UV protection. Ingredients. Although, resveratrol, alone, performed similarly well to the combination, Dr Dennis Gross Alpha Beta Universal Daily Peel, Retinol is a derivative of vitamin A that can increase the rate of, However, initially, retinol can cause irritation and dryness of the skin by damaging the skins barrier and increasing transepidermal water loss (TEWL), Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration, Some evidence suggest that this is due to its ability to increase the levels of ceramides, free fatty acids, and cholesterol in the stratum corneum. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration, Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier, A complete mixture of all three substances needs to be applied in order to repair the skin’s barrier function and, In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application, However, not only do all three substances need to be combined for maximum hydration and barrier repair, but they need to be combined in a specific ratio of between 1:1:1 to 3:1:1 (ceramides: cholesterol: free fatty acids), with ceramide-dominant formulations being more suitable for some skin conditions, Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. Poli, F., Ribet, V., Lauze, C., Adhoute, H. & Morinet, P. (2005). (2007). Salicylic acid has relatively natural origins, as it was once derived from the metabolism of salacin, often found in the bark of willow trees. As you can imagine, the two combined may be quite irritating for skin. Blog About Shop Contact Media Kit Disclaimer. Ceramides account for about 45-50% of this mixture, cholesterol for approximately 25%, and free fatty acids for around 10-15% [25]. which results in rougher and duller looking skin. Frankly, I have never suffered from severe acne, but based on … N-Acetyl Glucosamine (NAG) is an amino sugar and precursor to hyaluronic acid that inhibits tyrosinase glycosylation, thus reducing melanin production [61]. Theyre the miracle tools used to fight acne, wrinkles, age spots, scarring, and uneven skin tone. Specifically, a mix of 0.5% ferulic acid and 1% vitamin E with 15% vitamin C increases the effects of vitamin C eight-fold (8x) [19]. Products That Combine Retinol & Niacinamide: Although the combination of glycolic acid and vitamin C may not be suitable for all skin types, they make a powerful pairing. Layering and mixing skincare ingredients can be overwhelming at the best of times. They have very specific products for any skin type and any concern, at a very low price rate. For this reason, antioxidants and sunscreens make a perfect pairing and are much more effective when used together. Salicylic acid can improve the signs of premature skin aging by increasing collagen levels, improving the quality of elastic fibers, and shrinking pores for a smoother complexion, as well as reducing redness and pigmentation and improving skin barrier function, As salicylic acid is oil-soluble, it easily penetrates pores in order to unclog them by loosening and detaching the skin cells and debris that build up within the hair follicle, This also means that salicylic acid can access sebaceous glands and reduce sebum production, Niacinamide reduces sebum production by decreasing the glyceride and fatty acids of surface sebum which helps to, Enlarged pores are caused by two main factors; increased sebum levels and reduced levels of collagen and elasticity in the skin. I also wanted to add in a bha product, so I purchased Paula's Choice 1% salicylic acid liquid exfoliant. ‘Caffeine’s mechanisms of action and its cosmetic use’. But are some sunscreen ingredient combinations better than others? ‘Characteristics of the aging skin’. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67% [39]. Keen, M. & Hassan, I. Its effects are thought to be largely due to various saponins contained within centella asiatica extracts [33]. Here are 12 combinations of skincare ingredients that work better together! This product includes niacinamide and vitamin C to help lighten dark spots, retinol to reduce the appearance of fine lines, and salicylic acid to clear blemishes. I haven't used any product wi Kornhauser, A., Coelho, S. & Hearing, V. (2010). This is particularly relevant for individuals with hyperpigmentation and melasma as visible light can increase melanin production [41]. Mao-Qiang, M., Feingold, K., Thornfeldt, C. & Elias, P. (1996). AHAs, such as glycolic and lactic acid, act as chemical exfoliants and help remove dead skin cells and loosen the top layer of skin. Golden, G., Guzek, D., Kennedy, A., McKie, J. Wang, C., Huang, C., Hu, C. & Chan, H. (1997). ‘Complimentary antioxidant function of caffeine and green tea polyphenols in normal human skin fibroblasts’. This suggests that application of niacinamide is able to prevent the typical irritant effects often experienced upon commencing retinol treatment. A number of studies that have investigated the wound-healing benefits of centella asiatica have found that topical application of the extract increases the production of collagen [34]. Great for acne breakouts, salicylic acid shrinks them up, and fast. N-Acetyl Glucosamine + Niacinamide = Reduced Pigmentation. Products That Combine Ceramides & Cholesterol & Fatty Acids: Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. In addition, AHAs increase the rate of skin cell turnover which helps bring skin pigment to the surface of the skin faster where it can be shed as part of normal epidermal desquamation (skin shedding) [46]. In one study, individuals on a hydroquinone treatment regime were provided with a standard broad-spectrum SPF50 sunscreen or a similar sunscreen that also contained iron oxide and instructed to apply it every day. Exfoliation or Masking (Optional) This is a completely optional step (skip to number 3 or 4 if don’t … Deciem Responses Regarding Conflicts & The Ordinary Products You Can & Cannot Mix Why can´t I now use Vitamin C derivatives with Niacinamide? Resveratrol + Glycolic Acid = Reduced Hyperpigmentation. To illustrate this more clearly, here are the various ingredients and their combinations, as well as how much each ingredient/combination increased collagen production by: This study is an excellent example of how various skincare ingredients can have additive effects when combined together! Ash, K., Lord, J., Zukowskl, M. & McDaniel, D. (2013). ‘Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety’. Scientific research studies are here to help us out! Some research suggests that iron oxide can increase the overall sun protection offered by zinc oxide sunscreens by absorbing all wavelengths of visible light [40]. Another antioxidant skincare ingredient that promotes wound-healing and boosts collagen production is vitamin C [19]. My other concern is can i use more of the same product in a skin care routine. Siu, S., Ferzili, G. & Brody, N. (2017). ‘Stratum corneum lipid phase transitions and water barrier properties’. ‘Nicotinic acid/niacinamide’. For example, a combination of retinaldehyde and glycolic acid demonstrated a good tolerability and significant improvement in acne lesions after 1-3 months of use [58]. ‘Post inflammatory hyperpigmentation: etiologic and therapeutic considerations’. I have long accepted that my skin will never be free from blemishes and oil-overproduction. I did learn alot from reading your article. Use salicylic acid (psoriasis or seborrheic dermatitis) as ordered by your doctor. Bissett, D., Robinson, L., Raleigh, P. et al. Hakozaki, T., Minwalla, L., Zhuang, J. et al. ‘Efficacy and safety of a new superficial chemical peel using alpha-hydroxy acid, vitamin C and oxygen for melasma’. They are all skin care lines that focus on clinical formulas. In addition, free radicals are also produced by other forms of solar radiation, including visible light and infrared radiation. In short, salicylic acid is beta hydroxy acid (BHA) that penetrates deep into the pores and exfoliates. & Gajjar, A. This multi-functional niacinamide serum is a perfect solution for those dealing with both acne and its aftermath. Farage, M., Miller, K., Elsner, P. & Maibach, H. (2013). Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens [22]. A number of in vitro and in vivo studies have demonstrated that these lipids, particularly ceramides play a vital role in skin hydration by regulating the amount of water in and out of the skin [26][27]. Resveratrol is the potent antioxidant found in grapes (and red wine!) One study found that a topical combination of vitamin C and a centella asiatica extract significantly improved skin suppleness, firmness, and hydration, as well as improving the appearance of wrinkles, after 6 weeks of use, Glycolic acid, an alpha-hydroxy acid that is thought to boost collagen production, was also included in this study. You can use a serum or moisturizer to rebalance your skin. Because of its ability to reduce inflammation, decongest pores and assist with exfoliation, it is commonly used to treat acne," McBride explains. (2002). But we’re already using the last skincare ingredient that they recommended and it has become our new holy grail product. With its offer of retinoids, direct acids, oils and more straightforward products, The Ordinary is known to be a very humble and no-nonsense brand. Hyaluronic acid and niacinamide are both water-based treatment and they can be used together. ‘The effect of Centella asiatica, vitamins, glycolic acid and their mixtures preparations in stimulating collagen and fibronectin synthesis in cultured human skin fibroblast’. Like salacin, salicylic acid is an anti-inflammatory substance with chemical similarities to aspirin. Haywood, R., Wardman, P., Sanders, R. & Linge, C. (2003). The name's pretty new too me. The fact that I no longer had an easy skin type was both a physical and a mental problem for me and it inspired me even more to read into skin care and get to the bottom of the problem. This means that combining the two can have an additive effect. How To Make Your Face Smooth (According To 20+ Research Studies), 12 Combinations Of Skincare Ingredients That Work Better Together, Vitamin C & Vitamin E (& Bonus Ferulic Acid), Centella Asiatica & Vitamin C (& Bonus Glycolic Acid), A Summary Of The Skincare Ingredients That Work Well Together. In fact, it can actually stop the visible signs of skin aging when used correctly [7]. But with so many acids on the market, it can seem overwhelming to remember which to use and for what and which products to buy. She has experience in plastic and reconstructive surgery, dermatology, and aesthetics and has received training in laser treatments. For example, vitamin C helps to regenerate vitamin E, making it more readily available to protect the skin from free radicals. Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration [51]. ‘Applications of hydroxyl acids: classification, mechanisms, and photoactivity’. Gehring, W. (2004). Salicylic Acid + Niacinamide "Salicylic Acid is a pore-cleansing Beta Hydroxy Acid (BHA). Retinol also helps to improve acne by increasing the rate of skin cell turnover and renewal which means that dead skin cells are shed quicker [49]. Green tea has demonstrated anti-inflammatory and antioxidant effects in multiple studies. Research suggests that niacinamide can decrease the transfer of melanosomes from melanocytes to keratinocytes by up to 68% and interferes with the cell signalling pathways between keratinocytes and melanocytes [63]. Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier [29]. In addition, vitamin C is one of the few examples in life where three is not a crowd. While some skincare ingredients work against each other or irritate skin when combined, others can enhance each others effects. Vitamin C and glycolic acid are also useful for treating hyperpigmentation as both are effective at inhibiting tyrosinase and decreasing melanin production, When used together, vitamin C and glycolic acid demonstrated an ability to significantly improve hyperpigmentation, as well as reduce pore size and improve, Other research has found that glycolic acid and vitamin C combinations are particularly good at treating stretch marks by increasing epidermal and papillary dermal thickness, This further highlights an anti-aging benefit of vitamin C and glycolic acid combinations as epidermal and papillary dermal thicknesses both decrease with age leading skin to become more transparent, Another skincare ingredient combination that is often shunned due to its irritation potential is that of retinol and alpha-hydroxy acids (AHAs). Infrared radiation accounts for about 53% and visible light accounts for about 39-44% of total solar radiation [11]. In some instances, this may lead to increased skin irritation, but this is not always the case. Chamlin, S., Kao, J., Frieden, I. et al. Centella Asiatica + Vitamin C + Glycolic Acid = Increased Collagen Production by 4x. ‘Sunscreens inadequately protect against ultraviolet-A-induced free radicals in skin: implications for skin aging and melanoma?’. All their products are cruelty-free and are not sold in China. ‘Efficacy and safety of 0.1% retinaldehyde/ 6% glycolic acid (Diacneal) for mild to moderate acne vulgaris’. You can use niacinamide in the morning and salicylic acid followed by … In addition, glycolic acid is very good at penetrating skin [47]. ‘Sunscreen and Prevention of Skin Aging: A Randomized Trial’. This suggests that application of niacinamide is able to prevent the typical irritant effects often experienced upon commencing retinol treatment. ‘Cosmeceuticals vitamins’. Whenever I feel breakouts coming up, so mostly right before and after my period and whenever I have a bad reaction to a product. This skin damage occurs when free radicals produced by UV radiation alter cellular DNA and break down the collagen in the skin [9][10]. I used to live their Salicylic acid but developed a bit of a sensitivity so now only the face mask. These two definitely address a certain skin type: the Niacinamide + Zinc is your best friend if you suffer from oily skin, and combined with the the Salicylic Acid it’s perfect to treat blemish- and acne-prone skin. Hydroxy acids are particularly useful for treating, For example, glycolic acid can significantly improve the resolution of the comedones, papules, and pustules commonly experienced with acne, Retinol also helps to improve acne by increasing the rate of skin cell turnover and renewal which means that dead skin cells are shed quicker. For this reason, topical application of vitamin C is required to maintain sufficient skin levels of vitamin C, Vitamin E is the most important lipid-soluble antioxidant in tissue and is particularly abundant in the outermost layer of the skin (the stratum corneum) where it is delivered by sebum. Just use them at different times. Tanno, O., Ota, Y., Kitamura, N., Katsube, T. & Inoue, S. (2000). Glycolic Acid + Vitamin C = Increased Collagen and Skin Thickness, Reduced Hyperpigmentation. (What Is Skin pH?). Other research has found that this is an additive effect. Products That Combine Centella Asiatica & Vitamin C: Products That Combine Centella Asiatica & Vitamin C & Glycolic Acid: As mentioned earlier, sunscreen is very very important for preventing aging and improving overall skin health. In one study, pre-treatment of the skin with niacinamide provided additional barrier protection and made the skin more tolerant of retinoic acid (a prescription strength version of retinol). ‘The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells’. We have already seen earlier how vitamin C and glycolic acid enhanced each others collagen-boosting effects when combined with centella asiatica [35]. Niacinamide and salicylic acid work together to calm and minimize breakouts, while licorice root extract and vitamin C help the niacinamide brighten hyperpigmentation and acne scars. Jo, D., Seok, J., Kim, S. et al. Read all information given to you. (2013). Niacinamide & Salicylic Acid Niacinamide, a water soluble form of vitamin B3, and salicylic acid, a beta-hydroxy acid, work particularly well when combined together. While UV radiation is the most damaging form of solar radiation for the skin, it only accounts for approximately 3-7% of total solar radiation. This further highlights an anti-aging benefit of vitamin C and glycolic acid combinations as epidermal and papillary dermal thicknesses both decrease with age leading skin to become more transparent [56]. The ordinary niacinamide worked brilliantly for me. That would be a bit too harsh. Specifically, 4% niacinamide combined with 2% NAG was significantly more effective at reducing pigmentation than a vehicle control formulation, Furthermore, niacinamide appears to have an additive effect when combined with NAG. ‘Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color’. Sincerely. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047947/, https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781118384824.ch10, https://www.ncbi.nlm.nih.gov/pubmed/17134422, https://doi.org/10.1111/j.1524-4725.2005.31732, https://www.ncbi.nlm.nih.gov/pubmed/952756/, https://www.ncbi.nlm.nih.gov/pubmed/24641601/, https://www.ncbi.nlm.nih.gov/pubmed/23732711, https://www.ncbi.nlm.nih.gov/pubmed/18377617, https://www.researchgate.net/publication/256618684_Free_Radicals_In_Biology_And_Medicine, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1751-1097.1989.tb05548.x, https://www.ncbi.nlm.nih.gov/pubmed/14632206, https://www.ncbi.nlm.nih.gov/pubmed/17205635, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1529-8019.2012.01505.x, https://www.sciencedirect.com/science/article/pii/S0022202X15358292, https://www.sciencedirect.com/science/article/pii/S0738081X09001254, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605218/#B3, https://www.ncbi.nlm.nih.gov/pubmed/18045356/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673383/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976416/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958188/, https://www.ncbi.nlm.nih.gov/pubmed/23075568, https://europepmc.org/abstract/med/21720657, https://www.jaad.org/article/S0190-9622(17)31504-9/fulltext, https://www.ncbi.nlm.nih.gov/pubmed/23951566, https://pubs.acs.org/doi/abs/10.1021/bi00382a045?journalCode=bichaw, https://core.ac.uk/download/pdf/82665629.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216025/, https://www.jaad.org/article/S0190-9622(02)00048-8/fulltext, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116297/, https://www.ncbi.nlm.nih.gov/pubmed/9731470/, https://www.researchgate.net/profile/Puziah_Hashim4/publication/260431233_The_effect_of_Centella_asiatica_vitamins_glycolic_acid_and_their_mixtures_preparations_in_stimulating_collagen_and_fibronectin_synthesis_in_cultured_human_skin_fibroblast/links/564aaf6208ae44e7a28dd030.pdf, https://www.ncbi.nlm.nih.gov/pubmed/18503551/, https://www.ncbi.nlm.nih.gov/pubmed/16311163, https://jamanetwork.com/journals/jamadermatology/article-abstract/552806, https://www.ncbi.nlm.nih.gov/pubmed/18248499, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936427/, https://www.ncbi.nlm.nih.gov/pubmed/21348540?dopt=Abstract, https://www.ncbi.nlm.nih.gov/pubmed/14756523/, https://www.sciencedirect.com/science/article/pii/S0923181104000982, https://link.springer.com/article/10.1007/s00403-016-1644-9, https://www.ncbi.nlm.nih.gov/pubmed/29663438, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/, https://www.spandidos-publications.com/ijmm/22/2/229, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1473-2130.2004.00115, https://www.ncbi.nlm.nih.gov/pubmed/8543691/, https://www.tandfonline.com/doi/abs/10.3109/14764172.2012.748199, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4725.1998.tb04262.x, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4725.1997.tb00003.x, https://www.karger.com/Article/Abstract/81498, https://www.karger.com/Article/Abstract/81500, https://www.ncbi.nlm.nih.gov/pubmed/17348991, https://www.ncbi.nlm.nih.gov/pubmed/20725554?dopt=Abstract, https://www.ncbi.nlm.nih.gov/pubmed/12100180, https://www.ncbi.nlm.nih.gov/pubmed/19845667/. (This happened to me, when I went from Biologique Recherche Lotion P50, which contains lactic acid, to COSRX BHA Blackhead Power Liquid, which contains salicylic acid—a much stronger acid.) In fact, a number of different skincare ingredients compliment and enhance the effects of others. If your makes your skin itchy, don’t use it all. Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer [23]. ‘Preliminary open-label clinical evaluation of the soothing and reepithelialisation properties of a novel topical formulation for rosacea’. ‘Topical retinaldehyde with glycolic acid: study of tolerance and acceptability in association with anti-acne treatments in 1,709 patients’. that is known to reduce pigmentation and inflammation and has anti-aging properties, It inhibits tyrosinase, the key enzyme in the production of melanin, in various ways and thus prevents the conversion of DOPA to melanin, Some research suggests that glycolic acid, as well as other AHAs, also inhibit tyrosinase, In addition, AHAs increase the rate of skin cell turnover which helps bring skin pigment to the surface of the skin faster where it can be shed as part of normal epidermal desquamation (skin shedding), In addition, glycolic acid is very good at penetrating skin, Recently, a hybrid of glycolic acid and resveratrol, resveratryl triglycolate, has demonstrated the ability to reduce sun induced pigmentation when applied twice daily for 6-8 weeks, When investigated separately, this combination of resveratrol and glycolic acid inhibited tyrosinase more effectively than glycolic acid alone. Same as AM but without SPF Niacinamide can help decrease retinol irritation, and on top of that, the added barrier function benefit definitely is a plus! The Problem with Mixing Niacinamide and Acid Together Farage, M., Miller, K., Elsner, P. & Maibach, H. (2008). ‘After 30 years…the future of hydroxyacids’.

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